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In this video clip, Dr. Bill Gurley discusses how St. Johns wort reduces the effectiveness of many medications.
To learn more about interactions between supplements and drugs, watch Dr. Gurley’s lecture \”Clinically Relevant Herb-Drug Interactions: Past, Present, and Future\” at https://nccih.nih.gov/training/videolectures/clinically-relevant-herb-drug-interactions.
Free CME and CE are available.
Bill J. Gurley, Ph.D., is a professor in the Department of Pharmaceutical Sciences and director of the Clinical Pharmacokinetics Laboratory at the University of Arkansas for Medical Sciences College of Pharmacy.
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5-htp vs. St. John’s Wort and the science behind it – brain feed
As an easy comparison between the two St John’s wort claims to stop the reabsorption of serotonin while 5-HTP increases the amount of serotonin overall.
Source: brain-feed.com
Date Published: 11/11/2022
View: 668
Amazon.com: Solaray 5-HTP Plus St John’s Wort – 100 mg
5-HTP is the precursor to serotonin, which is lacking in depression sufferers. This helps the body create more serotonin and the St. John’s Wort acts as a SSRI …
Source: www.amazon.com
Date Published: 3/29/2022
View: 7885
5-HTP Vs St John’s Wort – Which Should You Choose?
5-HTP and St John’s Wort should never be taken together. This is because taking both supplements alongse each other could increase the risk of …
Source: evonutrition.com
Date Published: 12/22/2022
View: 4366
5-HTP and st. john’s wort Interactions – Drugs.com
St. John’s wort 5-hydroxytryptophan … Using St. … Severe cases may result in coma and even death. You should seek immediate medical attention if you experience …
Source: www.drugs.com
Date Published: 6/1/2022
View: 5168
Solaray 5-HTP Plus St. John’s Wort — 30 Capsules – 100 MG
From natural Griffonia bean extract with St. Johns Wort… Clinical studies indicate that administration of L-5-hydroxyTryptophan(L-5-HTP) enhances …
Source: betterhealthmarket.com
Date Published: 1/19/2022
View: 8578
St John’s Wort vs 5 HTP: Which Has a Better Effect on …
So, essentially, St John’s Wort works in the same way as 5-HTP, but more broadly, affecting more neurotransmitters in a stronger way. This can …
Source: www.bellaallnatural.com
Date Published: 12/21/2021
View: 7905
Using St. John’s Wort with 5-HTP | Life Enhancement Products
Life Enhancement’s 5-HTP SeroTonic has a very slight amount of hypericin (the active ingredient in St John’s wort) in it, about 3% of the usual serving.
Source: life-enhancement.com
Date Published: 11/2/2021
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Is daily 100mg 5-HTP with 450mg St. John’s Wort safe … – Quora
I am not a fan of St. John’s wart. I love 5-htp which is directly converted to serotonin in your brain. It should always be combined with L-tyrosine.
Source: www.quora.com
Date Published: 10/18/2022
View: 8553
Solaray 5-HTP Plus St John’s Wort 100 mg – 30 Capsules
Solaray – Guaranteed Potency 5-HTP With Saint Johns Wort 100 mg. – 30 Capsules Supplement Facts Serving Size: 1 Capsule Servings Per Container: 30 Amount Per …
Source: www.walmart.com
Date Published: 10/23/2022
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Mood Joy – St Johns Wort and 5 HTP, Ashwagandha
Trio Nutrition’s Mood Joy Supplement. Mood Joy is stacked with a proprietary blend of natural traditional herbs with a 5 HTP base. Our joy supplement blend …
Source: www.trionutrition.com
Date Published: 12/20/2021
View: 2458
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- Date Published: 2015. 3. 18.
- Video Url link: https://www.youtube.com/watch?v=k8-4FJvQe6s
5-htp vs. St. John’s Wort and the science behind it
The St. John’s Wort (hypericum perforatum) plant has been a popular folk remedy for a variety of mental health conditions for centuries. Despite this, there isn’t a single study with the correct research methodology to support its use.
St John’s Wort tablets or other preparations include small amounts of the active ingredient, hyperforin. This is supposed to work to block the re-uptake of three chemicals found in the brain that regulate mood and emotions; norepinephrine, serotonin, and dopamine.
These are known as neurotransmitters as they help move chemical messages between neurons, or nerve cells, in the brain. It is believed that an imbalance in these chemicals is the basis for depression, anxiety or fatigue in some people. However, despite containing hyperforin, St John’s Wort has not been proven effective for treatment of major depression. [1]
Why doesn’t the science stack up?
The existing evidence, based on studies testing St John’s Wort, found no significant effect when used alone. There is also a lack of evidence about whether it works as a supplement.
St John’s Wort depression treatments are used in some European countries but have not been cleared in larger markets like the United States. In fact, St John’s Wort side effects combined with the lack of evidence for the positive impact of the plant, means the American Food and Drug Administration (FDA) has denied the plant’s products to be licensed for either prescription or over the counter treatments. [2]
What does St John’s Wort actually do?
The active ingredient of St John’s Wort, Hyperforin is supposed to improve mental health by keeping levels of norepinephrine, serotonin, and dopamine high. It does this by reducing the activity of re-uptake transporters which absorb and recycle neurotransmitters into the brain’s neurons. It also blocks the reabsorption (and so keeps levels stable) of GABA. That’s a neurotransmitter with a positive impact on relaxation and stress levels.[3]
5-hydroxytryptophan, known as 5-HTP, is a natural isolated nutrient which works by converting, upon ingestion, into serotonin (5-ht). That regulates mood and has been shown to be effective as a “natural antidepressant” and “works as well to treat depression as the popular SSRIs Prozac and Zoloft.”[4]
What is 5-HTP and how does it work?
Research has suggested that because 5-HTP is a building block of the mood-boosting chemical serotonin it may help with anxiety, sleep disorders, PMS, stress, depression, and fibromyalgia. As an easy comparison between the two St John’s wort claims to stop the reabsorption of serotonin while 5-HTP increases the amount of serotonin overall.
According to research by Birdsall, 5-htp is the transitional metabolite of L-tryptophan (LT), the essential amino acid in the biosynthesis of serotonin [5]. Serotonin, as described by Berumen et al., is a recognised neurotransmitter distributed brain wide with a particular presence in the hippocampus – a major component of the brain [6]. Serotonin levels have been connected to depression, mood disorders, the regulation of sleep, anxiety and pain sensation, among other conditions [7]. Nutrient precursors, such as 5-htp, have been shown to be effective in treating many of these conditions, as well as sharing promise for fibromyalgia and binge eating that is associated with obesity [8].
5-htp for depression
Research conducted by Nakajima et al., on patients with depression found that those who took 5-htp experienced marked improvements, some of whom noticed excellent progress within just one week [9]. A similar study by Alino et al., also found that patients who took nialamide + 5-htp as opposed to nialamide alone achieved a fuller recovery [8].
What are the risks of taking St John’s Wort?
There are other important considerations for those interested in natural supplements. Regardless of how big or small the St John’s Wort dosage, there may be serious side effects. It reportedly reacts badly with over 800 medications [10]. The most concerning of these is the risk of compromising birth control medication by taking St John’s wort at the same time. This is because the herb can affect the activity of certain enzymes.
Furthermore, it’s been suggested that consumers need higher awareness of taking St John’s Wort, as 47% of those undertaking a group trial of St John’s Wort to treat depression experienced side effects; one patient consequently requiring an emergency room visit. [11]
For this reason, it is important to discuss with your doctor or pharmacist before you start any course of supplements.
brain feed’s 5-htp supplements are the smallest yet most nutrient-dense tablets available on the market. The UK’s premium supplier, brain feed put your health and wellbeing front and centre of product design, using 100% naturally derived ingredients to drive results grounded in science. Made from the highest quality extracts taken from sustainable sources – in this case, from griffonia seeds – they are twice the strength of 5-htp available from Holland & Barrett and MyProtein, helping you to relieve your anxiety in an easy-to-swallow, reliable and consistent tablet.
References
[1] Leonard, M., Sapone, A. and Catassi, C. (2017). JAMA – The Latest Medical Research, Reviews, and Guidelines. [online] Jamanetwork.com. Available at: http://jamanetwork.com/journals/jama/fullarticle/193754 [2] Nordqvist, C. (2017). St. John’s Wort: Should I use it? [online] Medical News Today. Available at: http://www.medicalnewstoday.com/articles/174928.php [3] Stjohnswortinfo.com. (2017). Hyperforin Mechanism of Action | Science | St. Johns Wort Info. [online] Available at: http://www.stjohnswortinfo.com/science_mechanism.html [4] Alban, D. 5-HTP Benefits for Anxiety, Depression, Sleep. – Be Brain Fit. [online] Available at: https://bebrainfit.com/5-htp-benefits-side-effects/ [5] Birdsall, T.C., 5-Hydroxytryptophan: A Clinically-Effective Serotonin Precursor. Alternative Medicine Review, 1998. 3(4): p. 271-280. [6] Berumen, L.C., et al., Serotonin Receptors in Hippocampus. The Scientific World Journal, 2012. 2012: p. 15. [7] Trachte, G.J., T. Uncini, and M. Hinz, Both stimulatory and inhibitory effects of dietary 5-hydroxytryptophan and tyrosine are found on urinary excretion of serotonin and dopamine in a large human population. Neuropsychiatric Disease and Treatment, 2009. 5: p.227-235.11 [8] Alino, J.J., J.L. Gutierrez, and M.L. Iglesias, 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment of depressions. A double-blind controlled study. Int Pharmacopsychiatry,1976. 11(1): p. 8 [9] Nakajima, WT.,Y. Kudo, and Z. Kaneko, Clinical Evaluation of 5-Hydroxy-L-Tryptophan as an Antidepressant Drug. Psychiatry and Clinical Neurosciences, 1978. 32(2): p. 223-230. [10] Alban, D. (2017). Benefits (and Risks) of St. John’s Wort for Depression. Be Brain Fit. [online] Available at: https://bebrainfit.com/st-johns-wort-benefits-depression [11] Beckman, SE et al. (2000). Consumer use of St. John’s wort: a survey on effectiveness, safety, and tolerability. – Pub Med – NCBI. [online] Ncbi.nlm.nih.gov. Available at: https://www.ncbi.nlm.nih.gov/pubmed/10809344
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5-HTP Vs St John’s Wort – Which Should You Choose?
When looking for a more natural way to treat their depression, many people are faced with the choice of 5-HTP vs St John’s Wort. In this article, we’ll explain the benefits and drawbacks of each of these supplements, helping you to make the right choice.
A quarter of people in England experience a mental health issue every year, so it’s no wonder that more and more people are looking for more natural ways to manage their depression. 5-HTP and St John’s Wort are both popular choices when it comes to alleviating the symptoms of depression.
Should You Choose 5-HTP or St John’s Wort For Depression?
5-HTP and St John’s Wort are often seen as the main two alternatives to prescription medication for depression. Both are promoted as a natural remedy which can lift your mood and promote your mental wellbeing.
But which supplement is most effective and how do you know which is right for you?
Read on to discover the difference between 5-HTP and St John’s Wort and to find out which supplement is right for you.
Purchase 5-HTP supplements here
What Is 5-HTP?
5-HTP is an amino acid which is naturally produced by your body. This amino acid plays a key role in triggering the production of serotonin, the hormone which regulates your mood, sleep and appetite.
However, 5-HTP isn’t just produced in the human body. It can also be found within the seeds of the African plant Griffonia Simplicifolia. After being extracted from the seeds for Griffonia Simplicifolia, 5-HTP can then be made into naturally-derived supplements.
How Does 5-HTP Help Depression?
5-HTP is heavily involved in the production of serotonin. The more 5-HTP that you have in your body, the more serotonin your body is able to produce. That’s why, when you take 5-HTP supplements, the amount of serotonin that your body is able to produce increases.
Research has shown that serotonin plays an important role in regulating your mood, as well as impacting your sleep, appetite, sexual behaviour and pain tolerance. Increased serotonin levels have been found to alleviate depression, improve insomnia, suppress appetite and even help with migraines.
As 5-HTP is directly involved with serotonin production, taking 5-HTP supplements can help to increase the levels of serotonin in your brain, leading to an improvement in depression. That’s why many people rely on the effects of 5-HTP supplements to naturally improve their mental wellbeing and ease their depression.
Is 5-HTP Effective At Treating Depression?
It’s well known that a lack of serotonin in the body is one of the main causes of depression, so it’s not surprising that many people swear by 5 HTP for managing their depression.
The effects of 5-HTP are backed up by research too. A 2002 review of studies concluded that 5 HTP can be effective in treating depression, especially in patients who are resistant to therapy. Those taking 5 HTP supplements typically report increased mental wellbeing and a greater sense of relaxation – something that most sufferers of depression crave.
Although more research is needed for 5-HTP supplements to be seen as a mainstream treatment for depression, the evidence is promising and many people swear by its effects.
Click here to see our 5-HTP supplements
What Is St John’s Wort?
St John’s Wort is a naturally-occurring compound which is extracted from a star-shaped yellow flower known as hypericum perforatum. It has been used in alternative medicine across the world for thousands of years.
Many people take St John’s Wort to help to manage their depression. But how does it work and is it really safe and effective?
How Does St John’s Wort Help Depression?
St John’s Wort contains the active ingredient hyperforin. Research has shown that hyperforin can help to increase the body’s levels of serotonin, dopamine and norepinephrine. This is done by reducing the body’s ability to absorb and recycle neurotransmitters, meaning that they stay in your body for longer.
Increasing your body’s levels of serotonin, dopamine and norepinephrine can have a positive impact on depression and mental wellbeing. That’s why many people rely on St John’s Wort for managing their depression and improving their mood.
Is St John’s Wort Effective At Treating Depression?
The research is split when it comes to St John’s Wort. A number of studies have found it to be an effective treatment for depression, whilst others have found it to be no more effective than a placebo and to even have potential harmful effects.
A 2017 review found that St John’s Wort can be equally as effective as SSRI antidepressants for those suffering from mild to moderate depression. Conversely, a 2011 study found St John’s Wort to be no more effective than a placebo.
The effectiveness of St John’s Wort in treating depression is largely debated, with researchers firmly on both sides of the fence.
Buy 5-HTP supplements here
What Does The Science Say About 5-HTP And St John’s Wort?
The main difference between 5-HTP and St John’s Wort is that 5-HTP encourages the body to produce more serotonin whilst St John’s Wort attempts to prevent the re-absorption of serotonin.
The science seems to favour 5-HTP thanks to its high levels of efficacy and low risk of side effects. St John’s Wort, although still popular, appears to be falling out of favour after studies suggested that it was no more effective than a placebo during trials.
Research continues to be done on both supplements to establish the efficacy and safety of both potential treatments for depression.
Interaction With Other Medications
Another thing that should be considered before choosing to take either 5-HTP or St John’s Wort is the potential for interactions with other medications.
5-HTP is contraindicated for use with other medications that increase the body’s level of serotonin. This includes many SSRI antidepressants. This is because taking more than one medication that increases serotonin levels could lead to a dangerous condition known as serotonin syndrome, where your body has too much serotonin. However, 5-HTP is compatible with the majority of other medications.
St John’s Wort is known for its interactions with other medications. It’s been reported that St John’s Wort interacts with over 800 medications, including compromising the effects of birth control medications. In fact, the interactions of St John’s Wort can be so severe that countries such as France and Ireland have now banned its sale.
If you’re thinking of taking 5-HTP or St John’s Wort to treat your depression, it’s important to first check with your doctor or pharmacist to ensure that it won’t interact with any other medications that you may be taking.
5-HTP Or St John’s Wort – Which Should You Choose?
There are many different factors to take into consideration when you’re deciding between 5-HTP supplements and St John’s Wort, including efficacy, side effects and interactions with other medications. The choice of which supplement to take is personal and should be carefully weighed up after reading the research.
Find out more about our 5-HTP supplements here
Related Questions
Can I Take 5-HTP And St John’s Wort Together?
5-HTP and St John’s Wort should never be taken together. This is because taking both supplements alongside each other could increase the risk of serotonin syndrome. This condition is rare but is extremely serious. Symptoms of serotonin syndrome include seizures, increased heart rate, confusion, hallucinations and fever.
How Long Does It Take For 5-HTP To Start Working?
It can take up to 3 weeks for the full effect of 5-HTP to be achieved, so don’t be concerned if you don’t notice an immediate improvement to your depression. The improvement is likely to be gradual as the level of serotonin in your brain increases over time.
Is 5-HTP Better Than St John’s Wort?
5-HTP and St John’s Wort work in different ways. 5-HTP increases the amount of serotonin in your body whilst St John’s Wort tries to block the re-absorption of serotonin. The effects of 5-HTP seem to typically be stronger and faster than St John’s Wort, although not enough research has been done to conclusively say which supplement is most effective. Ultimately, the choice of which supplement to take is personal and should be based on your own needs, as everyone will react differently to different supplements.
Try 5-HTP For Depression Today
Many people rely on the effects of 5-HTP supplements for treating their depression and improving their mental wellbeing.
If you’re ready to try 5-HTP supplements to ease your depression, you can purchase vegan-friendly 5-HTP supplements from our online store.
5-HTP and st. john’s wort Interactions
Moderate St. John’s wort food Applies to: st. john’s wort
While you are taking St. John’s wort, you must not eat or drink certain foods and beverages that are high in tyramine. Eating these foods while you are taking St. John’s wort can raise your blood pressure to dangerous levels. This may cause life threatening symptoms such as sudden and severe headache, confusion, blurred vision, problems with speech or balance, nausea, vomiting, chest pain, seizure (convulsions), and sudden numbness or weakness (especially on one side of the body). Call your doctor at once if you have any of these symptoms. Foods that are high in tyramine include: air dried meats, aged or fermented meats, sausage or salami, pickled herring, and any spoiled or improperly stored beef, poultry, fish, or liver, red wine, beer from a tap, beer that has not been pasteurize, aged cheeses, including blue, brick, brie, cheddar, parmesan, romano, and swiss, sauerkraut, over the counter supplements or cough and cold medicines that contain tyramine, soy beans, soy sauce, tofu, miso soup, bean curd, fava beans, or yeast extracts (such as Marmite). Caffeine intake should be limited as well. You should avoid or limit the use of alcohol while being treated with St. John’s wort. Alcohol can increase the nervous system side effects of St. John’s wort such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. Talk to your doctor or pharmacist if you have any questions or concerns.
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5-HTP Plus St. John’s Wort
From natural Griffonia bean extract with St. Johns Wort… Clinical studies indicate that administration of L-5-hydroxyTryptophan(L-5-HTP) enhances synthesis of serotonin in the brain. This special product is a combination of natural L-5-HTP from the Griffonia bean and St. John’s wort herb. This combination is itended to provide clinical efficacy by several different mechanisms, in addition, this product is enterically coated to enable the capsules to bypass the enzymes in the stomach which would convert L-5-HTP to serotonin prematurely (before reaching the centeral nervouse system). The Criffonia Simplicifolia Extract in this prodcut is guaranteed to contain minimum of 98% L-5-HTP…Depression (bipolar/unipolar), Heart disease, Insomnia, ObesityBalances mood (specifically in bipolar behavior)Cuts time to fall asleep in half without disturbing sleep patternsReduces aggressionReduces appetiteIncreases beta-endorphin releaseCreates a more relaxed waking state within 45 minutesIncreases pain thresholdReduces severity of Parkinson’s Disease symptomsReduces severity of migraine headache symptoms
Helpful Tips:
*Take two hours before or after meals
*Take with high carbohydrate (sugar) snack or liquid such as orange juice
*Avoid high protein meals close to taking 5-HTP to allow maximum assimilation
*Supplement Vitamin B3 (niacin) to prevent breakdown of 5-HTP to niacinamide
Directions For Use:As a dietary supplement, take 1-4 capsules daily, preferably in divided doses, with a meal or a glass of water.
St John’s Wort vs 5 HTP: Which Has a Better Effect on Happiness?
In the world of mood-altering substances, there are a huge array of different options. Some of them are extremely potent and dangerous, mostly scheduled and regulated or illegal drugs. Some of them are potent pharmaceuticals. Some of them are actually found in nature, and while their effects aren’t as pronounced as isolated, pure pharmaceuticals, they can still have a noteworthy impact.
We live in a difficult era. The pandemic has put all of us on edge, our lives upturned, and the stresses of daily life compounded. It’s no wonder that people are seeking out any treatment and supplement they can find to bolster their mood.
Two such substances are St John’s Wort and 5HTP. What are they, how do they work, and which is better? Let’s dig in.
What is 5-HTP?
While the name 5-HTP might seem like a scary chemical, it’s really not. 5-HTP is a common chemical in the body, and you probably are more familiar with it by a different name: Tryptophan. More specifically, it is known as 5-Hydroxytryptophan or Oxitriptan. It’s an amino acid, a chemical precursor used by the body to produce other chemicals, and is an intermediate chemical used in the production of serotonin.
5-HTP is also a byproduct of your body digesting and utilizing the precursor L-tryptophan, which can be found in a variety of different foods and supplements. When you see it commercially, though, it’s usually an extract of a specific plant, called the Griffonia Simplicfolia.
Serotonin is a powerful neurotransmitter used for a wide range of different cognitive and mood functions in the brain. It’s responsible, in whole or in part, for everything from mood, cognition, learning, memory, vasoconstriction, and even the vomiting response. It’s even a key component of your brain’s reward center, making you feel happiness and pleasure when good things happen.
Despite being a neurotransmitter in the brain, the majority of the serotonin in the body is produced and stored in the gastrointestinal tract and activates your brain through the Gut-Brain Axis.
How Does 5-HTP Work?
In order to understand how 5-HTP works, you should understand how serotonin works. When your body needs it, serotonin is used as a neurotransmitter, passing messages from one part of your body to another or to your brain. When it’s done with its message delivery job, it’s taken back up by the bloodstream and either reused or decomposed into component parts for other uses.
Many mood disorders, including anxiety and depression, are often issues with serotonin. They may be caused by serotonin not staying in your bloodstream or your brain enough, depriving the receptors of what they expect. You end up lacking happiness responses, having a sour mood, and suffering from more stress more often.
Pharmaceutical medications, largely anti-depressants and anti-anxiety medications, are part of a class called SSRIs. SSRIs are Selective Serotonin Reuptake Inhibitors. Essentially, they lay in wait, and they trap serotonin in with the receptors, giving you more serotonin responses before the serotonin is taken back up and broken down. Another class, SNRIs, are Serotonin-Norepinephrine Reuptake Inhibitors. They work the same way, but they target both serotonin and norepinephrine, also known as noradrenaline, the neurotransmitter responsible for some stress and the fight-or-flight response.
This is all a dramatic oversimplification of how these bodily processes work. We’re not cellular biologists, after all. We’re just paraphrasing from people who are much more educated on these matters.
Where does 5-HTP play into this? Well, it works to create more serotonin in the body. More serotonin means better serotonin responses, and thus less depression, less anxiety, a better mood, more happiness, and an overall better outlook on life.
Drawbacks to 5-HTP
If this is a great treatment for depression and anxiety, why don’t we use it all the time? Well, there are a few possible reasons.
First and foremost, we’re just not sure how effective it is. There have been quite a few small studies performed over the years into the efficacy of 5-HTP, but very few of them are rigorous. Many of them have flaws, such as:
Their sample sizes are too small to be scientifically relevant.
Their experiments aren’t properly controlled, so there’s no way to tell if they had a real impact.
The studies are funded exclusively by people selling 5-HTP supplements and aren’t properly analyzed.
There’s a lot of low-level and anecdotal evidence to support claims that it works, but there have been very few rigorous, controlled studies to determine whether or not that’s actually true. Still, it’s not a controlled substance and is sold over the counter in a variety of different forms, so it’s easy enough to try it to see if it works for you.
One of the more defined problems with 5-HTP is just its short half-life. It doesn’t take very long before the body absorbs, processes, and discards it, so it doesn’t have a very long effective duration. This might make it a poor supplement simply because its effects wouldn’t last long enough to be truly mood-altering.
There are also some side effects. 5-HTP might cause nausea, heartburn, vomiting, indigestion, sexual problems, drowsiness, and muscle problems. There’s also the possibility that it might cause a condition known as eosinophilia-myalgia syndrome, though records of this happening may have come from contaminants and not the 5-HTP itself.
If you’re diagnosed with depression or anxiety and you’re on a drug to treat it, that drug likely also interacts with your serotonin, either the production or the reuptake of the chemical. Taking 5-HTP may interfere with the proper functioning of this medication, so you should always consult your doctor before using it for any length of time or in any high dosage.
What is St John’s Wort?
St John’s Wort is an herbal remedy. It is the plant known as Perforate St John’s Wort, known scientifically as Hypericum perforatum, which is common around the world. It was originally located in the temperate climate bands in Europe and Asia, but was introduced as a wildflower and is now an invasive weed in North America, South America, South Africa, and Australia. In other words, you can find it pretty much anywhere these days.
The herb has been known and used as a remedy for literal millennia, stretching back to the time of antiquity in 30CE. Like many herbal remedies, it has been used to treat just about anything. Seriously, there’s a list here. People have used it (ineffectually) to treat everything from ADHD to cancer to migraines to psoriasis to herpes to fibromyalgia to excitability. There’s zero evidence it works for any of those.
How Does St John’s Wort Work?
The active ingredient in St John’s Wort is Hyperforin. Hyperforin is a phytochemical (plant chemical) with a lot of potential effects. Here, let’s quote Wikipedia and show you what we usually deal with, and what we explain to you in plain English:
“Hyperforin may be a constituent responsible for the antidepressant and anxiolytic properties of the extracts of St. John’s wort. In vitro, it acted as a reuptake inhibitor of monoamines (MRI), including serotonin, norepinephrine, dopamine, and GABA and glutamate, with IC50 values of 0.05-0.10 μg/mL for all compounds, with the exception of glutamate, which is in the 0.5 μg/mL range.[18] In other laboratory studies, hyperforin induced cytochrome P450 enzymes CYP3A4 and CYP2C9 by binding to and activating the pregnane X receptor.”
In other words, it’s similar to 5-HTP in terms of effect, except it’s not as selective. Instead of focusing on serotonin, it deals with a whole lot of different neurotransmitters and monoamines, including norepinephrine and dopamine.
So, essentially, St John’s Wort works in the same way as 5-HTP, but more broadly, affecting more neurotransmitters in a stronger way. This can be good because it has a stronger effect, but it can also be bad.
Drawbacks to St John’s Wort
One of the biggest drawbacks to St John’s Wort is that its effects are almost pharmaceutical-level strong. Unlike pharmaceuticals, however, it’s unregulated, unrefined, and potentially impure. This means from dose to dose, it might not have the same effects, and that can cause a range of different issues like mood swings.
St John’s Wort is also relatively short-lasting, similar to 5-HTP. It may be effective in the short term but might not work as a long-term solution to mood disorders or depression.
St John’s Wort also has a lot of potential side effects. These include:
UV Sensitivity . Taking St John’s Wort in large doses over time can cause excess light sensitivity, which means you’re much more susceptible to sunburns and skin disorders.
. Taking St John’s Wort in large doses over time can cause excess light sensitivity, which means you’re much more susceptible to sunburns and skin disorders. Trouble Sleeping . Insomnia is a common side effect of this supplement.
. Insomnia is a common side effect of this supplement. Vivid Dreams . Some people might not consider this a negative side effect, but it’s a tangible one.
. Some people might not consider this a negative side effect, but it’s a tangible one. Nervousness, trouble sitting still, and irritability . Mood disorders are vastly complicated, and anything that messes with neurotransmitters can have wide-ranging effects if it’s even a little out of balance.
. Mood disorders are vastly complicated, and anything that messes with neurotransmitters can have wide-ranging effects if it’s even a little out of balance. Stomach upset .
. Tiredness . This goes hand-in-hand with insomnia.
. This goes hand-in-hand with insomnia. Dizziness .
. Headache .
. Skin rashes .
. Dry Mouth.
Now, obviously, there’s no guarantee you’ll experience side effects, and if you do, you certainly aren’t likely to have everything on the list. Still, it’s a lot of possible ways for the supplement to go wrong.
Perhaps more dangerous than all of the above is that St John’s Wort can interfere with a wide range of medications.
Anything that interacts with serotonin . Most depression medications, SSRIs, SNRIs, and other medications can interact negatively with St John’s Wort.
. Most depression medications, SSRIs, SNRIs, and other medications can interact negatively with St John’s Wort. Anything with sun sensitivity as a side effect . In particular, the cancer medication aminolevulinic acid causes sun sensitivity that can be exacerbated by St John’s Wort.
. In particular, the cancer medication aminolevulinic acid causes sun sensitivity that can be exacerbated by St John’s Wort. Estrogen. Estrogen supplements, either used for gender transitioning or for birth control, are processed by the body and used. St John’s Wort increases the rate the body breaks down estrogen, and thus decreases the efficacy of the estrogen for its stated purpose.
There are dozens of medications that have identified reactions to St John’s Wort, generally all the same reaction: breaking down faster and becoming less effective for it. You can read the full list here.
Which is Better for Your Happiness?
The answer to this final question is a very complicated one, and it depends on your personal situation.
Essentially, you have to answer three questions.
What is your mood issue? Do you have minor mood imbalances, do you have major anxiety and depression, or something in between?
Do you have minor mood imbalances, do you have major anxiety and depression, or something in between? What is your current treatment plan? Are you on existing medications?
Are you on existing medications? What is your goal?
For people who have minor mood disorders and who are not currently receiving treatment for those issues, we recommend sticking with 5HTP. The effect is relatively minor, but it’s also relatively safe.
For people with middling or major disorders but who are not currently receiving treatment for them, you can try St John’s Wort. We’d recommend it as part of a balanced supplement.
Be sure not to take too much of it, and always make sure you’re not taking a medication that could be interfered with.
For people who are currently receiving treatment via medication for anxiety, depression, cancer, or any of a wide variety of other health issues, we strongly urge you to consult your doctor. St John’s Wort might be a way to enhance your mood, but you definitely don’t want to take it if it will interfere with your other treatment.
So, to sum up, you can put it this way: St John’s Wort is much stronger, but it’s a double-edged sword. It has the potential to help you quite a bit – at least for mood issues – but it also interferes with a lot of other treatments. Use it, but use it carefully.
Meanwhile, 5-HTP is much safer to use but has a much shorter and less pronounced effect when you take it. Feel free to do so, but be aware that it might not work for very long, and it might not be very strong when it works. As always, though, every person reacts differently to supplements, so it may be more or less effective for you than for us or for others, you know. And, as always, consult your doctor if you experience any major side effects of either supplement.
Using St. John’s Wort with 5-HTP
QUESTION: I have been taking 5-HTP for the past week and I feel incredible except for in the mornings I am slow to wake up. I used to take Zoloft daily. Since I started the 5-HTP I stopped taking the Zoloft. I was wondering if combining the 5-HTP with St. John’s wort would help the effects in the morning since I take the 5-HTP at night. I am taking 5-HTP for depression and weight loss. I have lost 8 pounds in one week with the 5-HTP. Thanks in advance for the advice.
WW
ANSWER: I have received many reports about taking 5-HTP with the usual recommended amounts of St. John’s wort having caused some users to experience hyperactivity or racey type feelings. Your thought about using St. John’s wort for the morning may be helpful. However, it might be best to start with very low doses of St John’s wort and then gradually increase your dose. This way you can see how your particular body chemistry responds. Life Enhancement’s 5-HTP SeroTonic has a very slight amount of hypericin (the active ingredient in St John’s wort) in it, about 3% of the usual serving. Contrary to some published material, my personal knowledge supports a real benefit (without side effects) at this lower level. Additionally, most people who try very small amounts of hypericin with 5-HTP seem to prefer it over straight 5-HTP. 5-HTP SeroTonic is available in 50 mg capsules, but is also available in powder (drink mix form) so you can measure out the exact dosage that you want, even a dosage of 10 or 25 mg.
Taking 5-HTP at bedtime is my usual recommendation. It can make some people drowsy, which is good for sleep disturbance but not good for daytime alertness. However, some people take 5-HTP in divided doses two or three times per day without any untoward effects. I suggest that you begin with lower amounts of 5-HTP and work your way up if you want to take it in the daytime.
It may also be of interest to you that there are many products available through Life Enhancement, containing information about using St John’s wort with 5-HTP.
Dr V
Happy Positive Mood Pills | Mood Joy
Stefanie B. I love this item. But you didn’t send in my last subscription and charged me for it. I sent an email to customer service and never heard back. I will be canceling my subscription.
Evonne M. Mood Joy has worked well for our family, and I have recommended it to many of my friends and contacts on social media.
Gwen Frericks Great product to buy!
Candie W. This simple to take capsule offered me energy and motivation. I have one cup of coffee in the morning and then take one Mood Joy capsule. It works fine for me.
Mary H This product is great. It’s made with high-quality ingredients.
Theo Bible Study and Mood Joy I was feeling in a funk due to covid. Over the past 2 months, I have joined a bible study group and started taking Mood Joy. Both seem to boost my overall moral and energy level.
Yollie Land I highly recommend drinking this before bedtime instead to ensure a restful night’s sleep.
Roy Bartone I’m not sure what to say because I haven’t noticed a difference yet.
Noah Zirkle My youngster adores these and uses them on a daily basis to combat anxiety.
Jennifer P The pills are quite appealing to me. It makes me feel better.
Eli Joel Pills were easy to take.
Sommer Grant Like you, I’m probably trying a variety of methods to avoid taking prescription medications, but I can’t say this is the solution, but it really seems like it is! My review is centered on my improved mood despite continuous external stresses that would ordinarily affect me but have not. Take a risk!
Anne Vicky I decided to give it a shot at bedtime. I take one and have a more restful night’s sleep and a calmer mood when I wake up and throughout the day. The level of anxiety has diminished. So far, everything has gone well ’14. I will buy from you again.
Theodora K This supplement literally saved my life! I’ve been battling severe postpartum depression, PTSD, and high anxiety for the past years. I’ve been on a number of antidepressants (SSRIs and SNRIs), anti-anxiety medicines, psychotherapy, and an Intensive Outpatient Program for PTSD too. I gave up hope of ever finding a depression solution. My state legalized marijuana, and I tried it for the first time this year, and it instantly lifted my spirits while simultaneously making me tired and bewildered. Then I came upon this supplement when looking for St. John’s Wort. I tried it, and after a few days, my sadness and fury had gone! I have energy instead of wanting to sleep all day. Suicidal ideation has disappeared. I take two in the morning (and one at night if I’m particularly triggered). If I don’t take it first thing in the morning, my anger and impatience return. I’ve been taking it for a few weeks and it’s given me the feeling that I’ve been given a second chance at life.
Matt You Get More Than 5-HTP Ever since entering college as an undergraduate, I started stressing about school, my life, my relationships, work and finances. I had tried several 5-HTP products before; but, Trio Nutrition’s Mood Joy seems to do the job for me. Not sure, but I’m guessing that it must have something to do with their proprietary formula that contains turmeric, St John’s Wort and other herbs. Highly recommend.
Trish England I took it for seasonal sadness and felt it helped, but when I attempted to stop taking it, I couldn’t! Even as I gradually reduced the amount, I had increased irritability, headaches, and anxiety (by dumping some of the pill out). So that’s a major drawback for me. But, it worked wonderfully for my seasonal sadness! I could still get out of bed in the mornings, I had motivation, I wanted to meet people, and I had very few terrible days. So that had a significant impact on me. It’s only a matter of getting off it!?
Matilde Meir These appear to improve my mood and help me relax so that I can fall asleep.
Trisha Page I’m wary of meds that aren’t “authorized,” but I needed to do something for my daughter, who was suffering from anxiety as a result of her Covid treatment. This works. Her anxiety had lessened after two days. She had never been nervous before. She is convinced that this product is the one factor that has made a difference. Try it out. You will not be let down.
Audrey France This did not work for me.
Karl Murray This product was quite beneficial for stress and anxiety relief. However, it had a significant negative effect on my health and that of my partner. A lot of weight was gained as a result of this. We gained extra weight due to welling in the body and joint ache. The problems went away in a week after we stopped using this, but after a month, we decided to try again, and the unpleasant symptoms reappeared. Despite the fact that it improves mood, I believe the herbs are interacting and perhaps causing kidney damage, resulting in water weight increase. I’m not a health care expert but products that haven’t been thoroughly tested yet, must be checked first.
Betty Colby I haven’t noticed any difference yet.
Shanon Softy I started taking it because I felt depressed throughout my period. I’d feel hollow and depressed for no apparent reason. I’d know there was nothing wrong logically, but I’d still cry. This hasn’t happened to me in months. It helped me to become more balanced.
Saul Willey This product worked perfectly!
Nicole Good I’ve been taking these every morning for the past month! I have anxiety and I wanted to try a few things before turning to pharmaceuticals. My energy level has improved. These aren’t a cure for depression, but they’ve helped me deal with it more effectively.
Susie Colleen I decided to test this product since I have difficulties sleeping and am easily bothered by stress. I’ve been taking them since the first day, and I’ve noticed that I’m feeling better, sleeping better, and being more relaxed. I am quite pleased and grateful to this company for producing a quality product; I will definitely try others and purchase this one again.
Cheryl Vokon I’m not sure if it helps with sleep, but it appears to help with mood.
Lynn Cole I had stomach cramps as a result of it. Both with and without food were tried.
Hana Paris For a long time, I’ve been dealing with mental health difficulties and not taking care of myself as I should. I felt lighter in my toes and less clouded in my thoughts after 2-3 days of using this. I’m tempted to buy this again after a week and a half. I’ve used antidepressants before, and without all the additives, this can be acquired easily. And it’s all organic! It’s fantastic.
Kris Flynn This supplement appeals to me because it is all-natural and has no side effects. The pill is little and easy to swallow. After two weeks of taking one capsule after a meal, I noticed a more even-keeled tone to my emotions and a general ability to relax. Stimuli didn’t bother me, but I did feel calmer and less worried. This is recommended for anyone looking for a natural approach to relax.
Orion Young I’m in a better mood.
Marlene Rupi A must-have purchase!
Jake Matthew I took them every day till I ran out and observed no difference.
Bam David Perhaps it works for some people. It made no difference to me.
Lucy B On a daily basis, I interact with the public, which can be exhausting. In about a week, I’ve noticed a significant difference, while using this. Happier, my sense of humor has returned and is still going strong! Much happier, and I will purchase again.
Allie Toy These have had a huge impact on my life. This has been a huge help in getting me through some very trying times in my life recently without causing any unwanted side effects Antidepressants and anti-anxiety drugs cause me a lot of side effects because I’m allergic to them. I don’t suffer from severe depression or anxiety, but certain days it may be tough to function. . I didn’t see a difference for approximately two weeks, but after a few days, I felt more at ease. Strongly advised.
Jaime Lamberson I tried every prescription drug available for several years. I also tried a few products, which helped a little but not enough to alleviate my anxiety and depression. One day, I came across Mood Joy and decided to give it a shot. I felt calm and relaxed almost immediately after taking it! I’ve never felt so good in my entire life!! I’m just hoping they don’t stop making Mood Joy!!!!! Anyone suffering from anxiety or sadness should take this natural supplement, in my opinion. It worked better for me than a prescription drug!The only issue is that it’s difficult to get in touch with Trio Nutrition since I’d like to ask certain things, such as if I can buy a year’s supply without worrying about it expiring too soon. I can only say that I will never stop using Mood Joy!!!! Thank you so much, Trio Nutrition!!!
Jacobson Cale I have a moderate depressive disorder that becomes worse during the dark winter months. These have helped me regulate my energy and mood. Expect no personality changes, but give them some time and you should notice a general improvement in their mood. These have performed better than any other natural depression supplements I’ve tried, and I’ll definitely keep using them.
Mau Cullen This is quite soothing. I take it and immediately feel at ease. It does not improve my sleep, but it does help me relax.
Kevin Silvia Awesome product. This has been quite beneficial.
Crystal Ernestine Fantastic product! It does exactly what it promises it will do!! It’s fantastic!!
Marcellus Rodriguez I’m experiencing less anxiety and am in a better mood.
Hans P This product made no difference to me, as of now. Others could benefit from it.
Mae Y I’m calm, relaxed, and stress-free! This is especially important if you’re a proactive person who is continually tired. Plus, using it with a chromium supplement can help you reduce stress and improve your health if you have high blood sugar.
Agustin D These are great! I take two pills a day, along with two maca pills, and it has significantly improved my mood. However, do not consume one on an empty stomach. It made me feel quite sick.
Keila Ricker I went to seek an alternative to prescription medication for my anxiety. My doctor recommended a few natural remedies for me to look into. Mood Joy contains several of the items on her list. And after just a few days, I saw a difference. I was able to cope with my anxiousness and general irritability. I have to take it with food or my stomach will be upset. Other than that, I haven’t had any negative effects.
Rebecca George I take these on a daily basis to help me relax. I’ll take these as long as they’re available.
Rod V Unlike other manufacturers, the capsule is very firm and well packed, so I don’t get the impression that I’m paying mostly for air. It has an egg white scent with a lite hint of vinegar. The tablet isn’t difficult to swallow; it’s small enough that even people with sensitive gag reflexes should be fine! The capsule has no texture, no chalky exterior, and no discernable “taste”; instead, it possesses the flavor of natural plant matter. This product has helped me to feel less stressed. This vitamin helps me maintain my cool. It’s actually rather enjoyable.
Von Boelk I’ve tried a variety of 5htp tablets and they’ve all made me nauseated. These haven’t made me nauseous at all, and I’ve found some inner peace with my anxiety so far. But, I have only been on them for a few days and cannot say whether they will make a substantial difference. So far, everything has gone according to plan.
Bry Feest This is fantastic!!! I was sick with a stomach illness for a few days and felt terrible. I feel and sleep so much better after using mood joy. I would recommend it to anyone suffering from depression.
Noel Kovacek This thing performs admirably. It helps me with some of the symptoms of Menopause.
William Francisco Until I took this, I was having a depressed episode unlike any other; now I take one first thing in the afternoon and glide through the day without stress or anxiety! I appreciate that it includes all of the products that are recommended for later in life! It’s a one-stop store for anyone turning 40 and beyond! No more waiting!
Lim Hudson My mood has not improved. I had to quit taking it since it didn’t worked for me and made me sick. It didn’t help me sleep either.
Nora Niger If you’re feeling down, gloomy, or worried, please do yourself a favor and try these. St. John’s Wort, Ashwaganda, Cayenne, 5-HTP, and other helpful compounds are included. The first time I used it, I took one before going to bed. I felt better the next morning than I had in previous years! My daughter (who suffers from depression) received some, but she is no longer depressed anymore! My kid was able to stop taking psychotropic medications that make her feel drowsy, thick, and sleepy, which I strongly oppose. She’s reverted to her previous state! I (and my daughter) take Sam-E (S-Adenosyl Methionine – also available on Amazon) every day and GET SOME SUN! Try this!
Peter A I’ve just had it for four days, and it’s quite easy to take. I’ll keep using it for mood.
Nicole Ochoa I’ve just finished my first bottle.
Hilda Moser I believe it is beneficial to one’s mood.
Romeo Oregon For me, 5-HTP has been a game-changer. It alleviates my mid-afternoon hunger. I’d want to try a different mixture like this because I believe in changing things up from time to time to give receptors a rest.
Henry S This product is fantastic. It contains excellent ingredients!
Taylor Smith I was happy to discover this supplement. It has been quite beneficial to my daughter.
Braun J The capsules are easy to take, and I saw a difference after only a few days. Each day, I feel well rested and cognitively clear, with less stress. Strongly suggested!
Sabrina Jenny My doctor recommended 5HTP to help me manage my terrible PMS. After just one month of using this product, PMS was almost non-existent! It also helps me to feel less tired. I’m much more energetic now. Strongly recommended!
Dominique George Mood Joy had no aftertaste and was easy to absorb. After two months of use, I felt relaxed and calm. I recommend it.
Danielle Cat I’ve experienced a mild mood shift after using this product for a few weeks. I have some nervousness from time to time, and after taking these pills, I noticed that it improved slightly. While this pill did not completely eliminate my anxiety, I noticed that I was not grinding my teeth as much during the day like before. The relaxing impact also helped me relax, which made it easier for me to fall asleep, which is something I struggle with. I would strongly recommend this product to anyone who simply wants to relax and sleep better.
Gabriella Rolfson I’m not sure if it’s ineffective, as my friend claims, but it’s worked for me.
Moras Lamont This is a fantastic item. I was gloomy and feeling flat, before. It has improved my mood with no negative side effects. I intend to continue taking it because I can tell a difference.
Amy A It’s an excellent relaxant. I alternate it with another very comparable product. It appears to be working for me.
Judy Nolan This natural-component supplement is amazing. It has significantly reduced my anxiety symptoms. Because the chemicals take time to build up in your system, don’t expect to see results straight immediately. If you take it regularly, you will see the benefits.
Amanda Afton The capsules were easy to consume and left no unpleasant aftertaste. I’m not sure if it had any effect on my mood or emotions. I think I’ll need more than a month to feel the full effects; I’m not sure a month’s supply is enough, but I think it had a minor impact on my mood when things were stressful. I wasn’t as furious or agitated as I usually am.
Tyrell N I like this product since it calms me and tempers my mood – I’ve tried it in the morning and at night and find that it works best for me first thing in the morning to keep me focused but not agitated. This is becoming a standard for a healthy alternative to pharmaceutical medications.
Hill Goldner A great and nice product.
Martin Grant Mood Joy has made it easier for me to deal with everyday stress. The pill seemed to relax me, allowing me to focus better and complete my tasks. I’m sleeping better as well.
Rhian Hirthe I was under a lot more stress as an adult, which included caring for a parent and having to work every day. I began looking for sjw again after discovering these pills that had it. On the third day, I noticed a change in my mood. There is no rush or elation, just a sense of calm. I can now function as I should. All while taking one pill per day (I take mine first thing in the morning on an empty stomach) and feeling like a normal person for the first time in years. I will definitely purchase again.
Lisa Nora Mood Joy is great! It greatly improves my mood and gives me that additional rush of happiness to get me through the day! This natural happy pill comes highly recommended!
Gussie M I’m more relaxed than I was before. Sleep seems to come easily to me.
E Lenor This thing makes you feel better. After using this, my mood has gradually improved. There are so many things to be concerned about in our world right now, but this has kept me calm and focused on the things I can control rather than the things I can’t. Don’t be hesitant to give it a try and stick with it because the results did not come quickly for me.
Elaine Evans Excellent product. I’m a working mother of two who doesn’t get much sleep, but this gave me an energy boost and improved my mood by the second day.
Sharon Goyette This has certainly aided my child’s anxiety and mood. We noticed right away. Reordering. Especially considering we’re still in the midst of this high-stress quarantine.
Iris Valeria The packaging is appealing and colorful, and it includes all necessary information. I’m particular about the vitamins I take on a daily basis, so I wasn’t sure what to expect at first. I’ve been using Mood Joy for two weeks and I’m completely smitten!! The tablet was easy to swallow and left no unpleasant aftertaste. My serotonin levels have risen, which has made me happier, reduced stress, and improved my overall mood.
Betty Nannie This product has exceeded my expectations! I have placed a second order!
R E Calming Mood Joy has helped me cope better with everyday stress. The supplement seems to relax me so I can focus better and get my work done. I’m sleeping better too.
Kim God Send Love this!!! I missed a few days while I had a stomach bug and felt it majorly. I feel so much better and sleep so much better using mood joy.
Turner HArb I slept like a baby the third night. I was truly exhausted and fell asleep. That means a lot to me.
Renner Shannon My mood has improved overall. There are no unfavorable impacts.
Dion Graybill It isn’t working. Save money.
Jeremy Vandervort So far, everything has gone swimmingly. I appear to be more relaxed. With a hyperactive child running around, this was quite beneficial.
Samantha Works So far so good. I seem more relaxed with then. Much needed with a crazy toddler running around.
Cheryl Welch This appears to aid me when I have anxiety or other problems, and I like all of the ingredients in this product. It’s also easy to use.
Reynold M I awakened feeling emotional this morning, but thanks to this medication, I was able to shake it off!
Myra B It’s all good. I can clearly tell the difference.
Irene Rodriguez This was quite beneficial to my anxiety. It does have a relaxing impact on me. Worth a shot
Kristopher L I tried this and noticed a significant improvement in my anxiety and depression levels, as well as an overall better mood toward life, after just a few weeks. Would definitely recommend it if nothing else has worked for you or if you’d rather not be on a prescription drug.
ELS A Healthy mind supports a healthy body These give me the extra support to keep the right mindset. Stress and change can interrupt your balance, these supplements help restore what is depleted.
Sky Win Although this medicine improves mood, it had a side effect for me, which is excessive sleepiness. My co-worker thought I was sick because I could barely remain awake at my work after using this. I took it for some weeks to see if the adverse effect would go away, but it didn’t. I’m sure I’m not the only one affected in this way – it’s a possible 5-HTP side effect.
Rodger Do I started taking this a few weeks ago and have seen a huge difference in my mood and overall well-being! My anxiety was at an all-time high before I started taking the supplement, and I was just plain exhausted. I’m generally feeling great during the day and sleeping considerably better at night now.I’ll keep purchasing this on a monthly basis.
Purple Lacey I was blown away by the ingredients and how well they all worked together. After a tough day at work, I take this in the evening. After dinner, usually, I have a sense of peace, relaxation, and serenity after taking Mood Joy. All of the day’s ideas and sounds simply vanish. This is my new go-to for any tense situations! Thank you for restoring the peace and tranquility!
Francesca Kreiger It appears to work, and I enjoy that it only requires one pill every day.
Marcelo Nikolas With so many new supplements on the market these days, it’s difficult to tell what’s real. Mood Joy was made with all natural ingredients. I did notice a relaxing impact on the third or fourth day, with less anxiousness overall. This product has also helped me get some fantastic sleep. Although it is not a substitute for mental health meds if that is what you require, I would recommend this product to anyone who wants to relax a bit more or who is having trouble sleeping!
Emi Omante I’ve discovered that taking this in the evening helps me sleep better and reduces anxiousness. Excellent product!
Holly Krause I can tell I’m sleeping better and feeling better.
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